After his graduation from the medicine program at Trinity College of Ontario, Dr. Neville J. Lindsay arrived in Calgary on the first CPR passenger train in 1883. He practiced in Calgary as one of the first physicians in the area, and eventually spread his practice to various locations all over southern Alberta.

In 1884, Dr. N.J. Lindsay was elected into Calgary's first Town Council. Ten years later, he became the President of the Alberta Medical Association. In the late 1890's and early 1900's, Lindsay was in and out of the medical scene, as he took time off to pursue his other interests in the gold rush, masonry and real estate, all which were very promising at the time.

As a dedicated mason, Dr. Lindsay was an extensive contributor to the architecture of early Calgary. He was instrumental in the construction of the Bow River Lodge No. 1 in 1884, constructed the building of the Isis (MAC) Theatre on 1st Street between 11th and 12th Avenues SW, and bought the land, on which sits today's Lindsay Park Sports Centre, with grand intentions of developing it. Eventually, Lindsay ended up selling this land to the Canadian Northern Railway in 1911 for their rail yards which were also never realized.